A Lufthansa Boeing 747-800, registration D-ABYQ performing flight LH-511 from Buenos Aires,BA (Argentina) to Frankfurt/Main (Germany), departed Ezeiza Airport's runway 35 and completed what appeared to be an uneventful flight with a safe landing on Frankfurt's runway 07R about 12.5 hours after departure. A post flight inspection revealed however that two panels at the wing root fairing were missing, one about 3 square meters and the other 1 square meter. In addition, the right hand inboard flaps had been penetrated and received a hole about 50cm in diameter with part of the underlying honey comb material missing, dents and two holes were also found at the right hand wing. The panels were located near the departure runway in Buenos Aires. On Apr 10th 2018 the BFU reported that they have been informed about the occurrence and are currently collecting information to rate the occurrence.