A Lufthansa Cargo McDonnell Douglas MD-11, registration D-ALCE performing freight flight GEC-8340 from Frankfurt/Main (Germany) to Tel Aviv (Israel), was accelerating for takeoff from Frankfurt's runway 18 when the crew rejected takeoff at high speed (about 110 knots over ground) due to the failure of the #3 engine (CF6, right hand). The aircraft slowed safely and stopped about 1000 meters (3300 feet) short of the runway end. Emergency services responded and checked brakes and engine. The aircraft was towed to the apron, the runway re-opened about 50 minutes after the rejected takeoff. A ground observer reported the #3 engine emitted a loud bang and a streak of flame followed by less loud bangs and streaks of flames in regular intervals. The aircraft slowed and stopped on the runway.